Site-specific Recombination Mediated Genome Editing

Creative Biogene is a leading company offering the best Site-specific Recombination service for microbial genome editing. Our talented scientists have extensive experience in inversion, deletion or insertion of DNA. They would research closely with you to offer help in microbial genome editing.

Site-specific recombination is a type of genetic recombination in which DNA strand exchange takes place between segments possessing at least a certain degree of sequence homology. Site-specific Recombination (SSR) perform rearrangements of DNA segments by recognizing and binding to short DNA sequences (sites), at which they cleave the DNA backbone, exchange the two DNA helices involved and rejoin the DNA strands. Site-specific DNA recombination requires both a recombinase protein and a pair of repeated DNA sites at which recombination takes place. Counting on the number and orientation of the DNA sites, perhaps there can be an inversion, deletion or insertion of DNA (Figure 1.).

Site-specific Recombination Mediated Genome Editing

Figure 1. Schematic of different types of site-specific recombination events.

As a leader in microbial genome editing, Creative Biogene provides a "one-stop shop" tailored to your gene research needs. We have expertise in gene knockout, knock-in/replacement and site-directed mutagenesis. Our services range from resistance test to genome editing, clonal selection and validation. It's entirely customizable and flexible to fit how you run projects.

Workflow of SSR-mediated genome editing services

Site-specific Recombination Mediated Genome Editing

Creative Biogene is the premier institution to provide professional and comprehensive genome editing services in microbial. We have years of experience to meet your specific project needs in using the site-specific recombination to add value to your research project. Creative Biogene is dedicated to providing complete solutions for genome editing to help you every step of the way in your genome editing workflow. And we offer full-service for genetic modification which has been successfully achieved in microorganisms, such as E. coli, Salmonella, Streptomyces, Clostridium, Bacillus subtilis, cyanobacteria, Saccharomyces cerevisiae, filamentous fungi, and so on. Simply let us know how you want the genome to be edited. We will propose the best strategy for you.

References:
1. Haldimann, A., & Wanner, B. L. (2001). Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteria. Journal of Bacteriology, 183(21), 6384-6393.

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