Probiotics and Prebiotics Production Services

Today, probiotics and prebiotics are fundamental ingredients of fermented milks and yogurts, which account for the most important fraction of the overall market. Among them, probiotics are defined as “non-pathogenic micro-organisms, mostly of human origin, which confer a health benefit on the host and enable to prevent or improve some diseases when administered in adequate amounts”. While a prebiotic is “a selectively fermented ingredient that allows specific changes in the composition and/or activity of the gastrointestinal microbiota that confer benefits upon host wellbeing and health.”

In the market, the most widely used probiotics include lactobacilli, bifidobacteria and some non-pathogenic strains. These probiotic cultures include Lactobacillus rhamnosus GG, Saccharomyces cerevisiae Boulardii, Lactobacillus casei Shirota and Bifidobacterium animalis, which are by far the most studied probiotics with proven human health efficacy. For prebiotics, most of them are short-chain carbohydrates with a degree of polymerisation of 2 or more, which are not susceptible to digestion by pancreatic and brush border enzymes. It worth to mention that It is nowadays common to find probiotic foods (e.g. yogurts and fermented milks) with added prebiotics. Such a combination, in which the concentration of prebiotic is typically below 10 g kg−1, is known as a “synbiotic”.

Probiotics and Prebiotics Services at Creative Biogene:

Creative Biogene provides solutions for challenges at industrial scale production of probiotics and prebiotics. With novel techniques and economical sources, our team is able to obtain prebiotics, such as oligosaccharides, with high yields and relatively low production cost. Creative Biogene also enables low-cost production of concentrated cultures of probiotics with improved viability after storage, during the manufacturing process and during transit through the stomach. Creative Biogene facilitate researches in probiotic microencapsulation with different coating materials.

Recently, recombinant probiotics have been generated for therapeutic applications. Those bioengineered probiotics expressing foreign gene products to achieve specific function is highly desirable under certain circumstances. Creative Biogene provides services for microbial therapeutics with professional experiences. At Creative Biogene, we try to provide a solution to meet your unique needs and see things from your perspective. 


• Lactic acid bacteria
• Bifidobacteria
• Yeasts

• Inulin
• Fructo-oligosccharides
• Galacto-oligosccharides
• Soya-oligosaccharides
• Xylo-oligosaccharides
• Isomalto-oligosaccharides
• Pyrodextrins


• Strain selection
• Genetic modification
• Growth condition optimization
• Process monitoring and control
• Small and large-scale production

1. Figueroa-González, I., Quijano, G., Ramírez, G., Cruz-Guerrero, A. (2011) Probiotics and prebiotics: perspectives and challenges. Journal of the Science of Food and Agriculture. 91(8): 1341-1348.

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Creative Biogene is fully engaged in developing unique technologies that provide global scientists with high quality products and satisfactory services to facilitate the investigation of microbial researches.


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