Oncolytic Probiotics Mediated Thyroid Carcinoma Treatment

As one of the most common endocrine malignancies, thyroid cancer is cancer that develops from the tissues of the thyroid gland, with increasing incidence all over the world. Besides standard conventional chemotherapy, targeted therapy with kinase inhibitors has shown promise in advanced cases of thyroid cancer.

Targeted therapy for advanced thyroid cancer: kinase inhibitors and beyond

Fig.1 Targeted therapy for advanced thyroid cancer: kinase inhibitors and beyond

Multi-kinase-targeted inhibitors are emerging as novel therapeutic strategies, and currently five drug regimens are approved for use in clinical practice in the treatment of differentiated, medullary, and anaplastic thyroid cancer, with more options in the pipeline. Targeted therapy drugs which are generally available for thyroid carcinoma are listed below.

Target Types Agent Manufacturer Start Marketing Date
VEGFR-1, VEGFR-2, VEGFR-3, FGFR1, PDGFR, cKit, Ret Small molecule Lenvima Esai 2015
KIT, VEGFR, PDGFR, RAF Small molecule Nexavar Bayer 2005
MET, VEGFR1/2/3, ROS1, RET, AXL, NTRK, KIT, etc. Small molecule Cometriq Exelixis 2012
VEGFR 2-3, EGFR, RET Small molecule Caprelsa Sanofi 2011

In the field of cancer treatment, it was viewed that the bacteria have the ability to deliver tumor-specific anticancer genes and the potential tumor-targeting antitumor capability. Creative Biogene is dedicated to providing Complete Solutions for oncolytic bacteria genome editing to help you every step of the way in your genome editing workflow. We have expertise in gene knockout, knock-in/replacement and site-directed mutagenesis. We can do the co-research with you, and we think the result will be better with our experts working together.

The ideal criteria for the selection of therapeutic bacteria are as follows:

• non-toxic to the host
• selective for a specific type of tumor
• non-immunogenic
• harmless to normal tissue
• manipulated easily
• controlled

References
1. Khatami, F. , Larijani, B. , Nikfar, S. , Hasanzad, M. , & Tavangar, S. M. . (2019). Personalized treatment options for thyroid cancer: current perspectives. Pharmacogenomics & Personalized Medicine, Volume 12, 235-245.
2. Rao, S. N. , & Cabanillas, M. E. . (0). Navigating systemic therapy in advanced thyroid carcinoma: from standard of care to personalized therapy and beyond. Journal of the Endocrine Society(10), 10.

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