As one of the most common endocrine malignancies, thyroid cancer is cancer that develops from the tissues of the thyroid gland, with increasing incidence all over the world. Besides standard conventional chemotherapy, targeted therapy with kinase inhibitors has shown promise in advanced cases of thyroid cancer.
Fig.1 Targeted therapy for advanced thyroid cancer: kinase inhibitors and beyond
Multi-kinase-targeted inhibitors are emerging as novel therapeutic strategies, and currently five drug regimens are approved for use in clinical practice in the treatment of differentiated, medullary, and anaplastic thyroid cancer, with more options in the pipeline. Targeted therapy drugs which are generally available for thyroid carcinoma are listed below.
|Target||Types||Agent||Manufacturer||Start Marketing Date|
|VEGFR-1, VEGFR-2, VEGFR-3, FGFR1, PDGFR, cKit, Ret||Small molecule||Lenvima||Esai||2015|
|KIT, VEGFR, PDGFR, RAF||Small molecule||Nexavar||Bayer||2005|
|MET, VEGFR1/2/3, ROS1, RET, AXL, NTRK, KIT, etc.||Small molecule||Cometriq||Exelixis||2012|
|VEGFR 2-3, EGFR, RET||Small molecule||Caprelsa||Sanofi||2011|
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1. Khatami, F. , Larijani, B. , Nikfar, S. , Hasanzad, M. , & Tavangar, S. M. . (2019). Personalized treatment options for thyroid cancer: current perspectives. Pharmacogenomics & Personalized Medicine, Volume 12, 235-245.
2. Rao, S. N. , & Cabanillas, M. E. . (0). Navigating systemic therapy in advanced thyroid carcinoma: from standard of care to personalized therapy and beyond. Journal of the Endocrine Society(10), 10.