Oncolytic Probiotics Mediated Melanoma Treatment

Melanoma, also known as malignant melanoma, is the rarest and most severe type of skin cancer. It develops from the melanocytes, which are the cells in your skin that produce melanin. Melanomas are usually caused by genetic mutations resulting from exposure to ultraviolet (UV) rays from the sun. We know genetics also plays a role.  


As a form of molecular medicine, targeted therapy is a drug that blocks the growth of cancer by interfering with specific molecules involved in tumor growth. It is different to non-specific treatments like chemotherapy that simply attack all rapidly dividing cells indiscriminately. Targeted drugs disrupt specific molecules to treat melanomas that have certain gene mutations. Targeted drugs can shrink or control the growth of tumors in some people and help some people live longer.   

Target Types Agent Manufacturer Start Marketing Date
IL2RA, IL2RB, IL2RG Peptide immunopotentiator Proleukin CHIRON 1992
MEK/MAP2K1 Small molecule Cotelllc Roche 2015
BRAF, MEK Small molecule Tafinlar GSK 2013
CTLA-4 mAb Yervoy BMS 2011
PD-L1 mAb Opdivo BMS 2014
PD-L1 mAb Keytruda MSD 2014
MEK1/2 Small molecule Mekinist GSK 2013
BRAF Small molecule Zelboraf Roche 2011

In the field of cancer treatment, it was observed that the bacteria have the ability to deliver tumor-specific anticancer genes and the potential tumor-targeting antitumor capability.


Creative Biogene provides a "one-stop shop" tailored to your gene research needs. We have expertise in gene knockout, knock-in/replacement and site-directed mutagenesis. Creative Biogene is able to provide you the comprehensive oncolytic bacteria genome editing service, including traditional recombineering system, CRISPR/Cas 9 system and site-specific recombination system. Simply let us know how you want the genome to be edited. We will propose the best strategy for you.

1. Yuan, M., Huang, L., Chen, J. et al. The emerging treatment landscape of targeted therapy in non-small-cell lung cancer. Sig Transduct Target Ther 4, 61 (2019).
2. Torres W, Lameda V, Olivar LC, Navarro C, Fuenmayor J, Pérez A, Mindiola A, Rojas M, Martínez MS, Velasco M, Rojas J, Bermudez V. Bacteria in cancer therapy: beyond immunostimulation. J Cancer Metastasis Treat 2018;4:4.

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