Oncolytic Probiotics Mediated Lymphoma Treatment

Lymphomas are a group of tumors that begins in infection-fighting cells of the immune system, called lymphocytes. Treatment for lymphomas has advanced significantly as multiple novel targeted therapy approaches have been developed. Targeted therapy has the potential to be a highly effective therapy with more precisely and lower toxicity.

Target Types Agent Manufacturer Start Marketing Date
HDAC Small molecule Beleodaq Spectrum 2014
26S proteasome Small molecule Velcade Millenlum 2003
CD30(TNFRSF8) ADC Adcetris Takeda 2011
CD20(MS4A1) mAb Zevalin Spectrum 2002
BTK Small molecule Imbruvica J&J/Abbvie 2013
PIK3CA Small molecule Zydelig Gilead 2014
PD-L1 mAb Opdivo BMS 2014
CD20(MS4A1) Small molecule Gazyva Roche 2013
CD20(MS4A1) mAb Rituxan Roche 1997
HDAC Small molecule Istodax Celgene 2009
CD20(MS4A1) mAb Bexxar Smithkline 2003
HDAC Small molecule Zolinza MSD 2006

In the field of cancer treatment, it was observed that the bacteria have the ability to deliver tumor-specific anticancer genes and the potential tumor-targeting antitumor capability.

Gut Microbiome Analysis

As a leader in oncolytic bacteria genome editing, Creative Biogene provides a "one-stop shop" tailored to your gene research needs. We have expertise in gene knockout, knock-in/replacement and site-directed mutagenesis. Creative Biogene is able to provide you the comprehensive oncolytic bacteria genome editing service, including traditional recombineering system, CRISPR/Cas 9 system and site-specific recombination system.

Gut Microbiome Analysis

Creative Biogene is dedicated to providing Complete Solutions for oncolytic bacteria genome editing to help you every step of the way in your genome editing workflow. And we offer full-service for genetic modification which has been successfully achieved in microorganisms, such as E. coli, SalmonellaStreptomyces, Clostridium, Bacillus subtilisSaccharomyces cerevisiae, filamentous fungi, and so on. Simply let us know how you want the genome to be edited. We will propose the best strategy for you.

References
1. Yuan, M., Huang, L., Chen, J. et al. The emerging treatment landscape of targeted therapy in non-small-cell lung cancer. Sig Transduct Target Ther 4, 61 (2019).
2. Dougan, M., & Dougan, S. K. (2019). Programmable bacteria as cancer therapy. Nature Medicine.

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