Oncolytic Probiotics Mediated Liver Cancer Treatment

Liver cancer, mostly hepatocellular carcinoma (HCC), is a relatively rare form of cancer that has a high mortality rate. The development of personalized molecular targeted therapies for HCC has been ongoing for many years. Targeted therapies act on specific genes, proteins, or the tissue environment that contributes to the growth and spread of cancer.

Signal transduction in solid cancer cells including hepatocellular carcinoma.

Fig.1 Signal transduction in solid cancer cells including hepatocellular carcinoma.

For some types of cancer, molecular targeted therapies may act on better than other treatments. Targeted therapy drugs which are generally available for Liver cancer are listed below.

Target Types Agent Manufacturer Start Marketing Date
VEGFR2 mAb Cyramza Lilly 2014
VEGFR1, VEGFR2,  VEGFR3, PDGFR-β, Kit, RET, Raf-1 Small molecule Stivarga Bayer 2012
VEGFR-1, VEGFR-2, VEGFR-3, FGFR1, PDGFR, cKit, Ret, PD-1 Small molecule Lenvima Esai 2015
KIT, VEGFR, PDGFR Small molecule Nexavar Bayer 2005

In the field of cancer treatment, it was observed that the bacteria have the ability to deliver tumor-specific anticancer genes and the potential tumor-targeting antitumor capability. Creative Biogene is specializing in providing Complete Solutions for oncolytic bacteria genome editing to help you every step of the way in your genome editing workflow.

The ideal criteria for the selection of therapeutic bacteria are as follows:

• non-toxic to the host
• selective for a specific type of tumor
• non-immunogenic
• harmless to normal tissue
• manipulated easily
• controlled

Basic Service

• Bacterial Gene Knockout Service
• Bacterial Gene Knockin/replacement Service
• Bacterial Gene Site-directed Mutagenesis Service

1. Kudo, M. (2012). Targeted Therapy for Liver Cancer: Updated Review in 2012. Current Cancer Drug Targets, 12(9), 1062–1072.

For research use only.

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