Oncolytic Probiotics Mediated Cancer Treatment

In the field of cancer treatment, it was observed that the bacteria have the ability to deliver tumor-specific anticancer genes and the potential tumor-targeting antitumor capability. Lately, oncologists were successfully using bacillus Calmette-Guérin (BCG-attenuated strain of Mycobacterium bovis) as agent to prevent relapses of bladder cancer after surgical removal of the primary tumor. Bacteria offer multiple advantages as excellent candidates for anticancer drug delivery devices. It has been proven that Bacteria is able to activate the immune response besides causing tumor destruction. Other than that, antibiotics can be used to control bacteria if complications in further tumor treatment arise. Over recent decades, it has become evident that bacteria can be effective agents for cancer treatment – they are the perfect vessels for targeted cancer therapy.

bacteria utilized in anti-cancer therapy

Fig.1 bacteria utilized in anti-cancer therapy (NEHA NAIR, et al. 2014)

Recently, state-of-art genetic engineering has increased the ability to alter bacterial strains. Such alteration decreases bacteria side effects while increasing their therapeutic benefits for cancer. Creative Biogene is a leading company offering the best oncolytic bacteria genome editing service. Our talented scientists would research closely with you to offer help in bacteria-based cancer therapy.

Three main strategies in bacterial cancer treatment

• Bacteria as tumor markers;
• Bacteria engineered to express anticancer agents;
• Bacteria for oncolytic therapy. Bacteria exhibit the ability to manufacture and deliver specific materials;

Optional genome editing method

• CRISPR /Cas9-mediated Genome Editing Service
• Homologous Recombination-mediated Genome Editing Service
• Site-specific Recombination Mediated Genome Editing

Creative Biogene is dedicated to providing Complete Solutions for oncolytic bacteria genome editing to help you every step of the way in your genome editing workflow. And we offer full-service for genetic modification which has been successfully achieved in microorganisms, such as E. coli, SalmonellaStreptomyces, Clostridium, Bacillus subtiliscyanobacteriaSaccharomyces cerevisiaefilamentous fungi, and so on. Simply let us know how you want the genome to be edited. We will propose the best strategy for you.

References
1. Ríus-Rocabert, S., Pinel, F.L., Pozuelo, M.J., García, A., & Nistal-Villan, E. (2019). Oncolytic bacteria: past, present and future. FEMS microbiology letters.
2. Wang Y, Guo W, Wu X, Zhang Y, Mannion C, Brouchkov A, Man YG, Chen T. Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis. J Cancer 2019; 10(19):4442-4454.
3. Rolim, Mariado & Montenegro, Yorran & Ceballos, Antonio. (2019). Bacteria and cancer: Advances, perspectives and applications. Clinical Microbiology and Infectious Diseases. 4.
4. Nair, N. , Kasai, T. , & Seno, M. . (2014). Bacteria: prospective savior in battle against cancer. Anticancer Research, 34(11), 6289-6296.
5. Felgner, S., Kocijancic, D., Frahm, M., & Weiß, S. (2016). Bacteria in Cancer Therapy: Renaissance of an Old Concept. International Journal of Microbiology, 2016.
6. Liu, S. , Xu, X. , Zeng, X. , Li, L. , & Li, J. . (2014). Tumor-targeting bacterial therapy: a potential treatment for oral cancer (review). Oncology Letters, 8(6), 2359-2366.
7. Song, S. , Vuai, M. S. , & Zhong, M. . (2018). The role of bacteria in cancer therapy – enemies in the past, but allies at present. Infectious Agents & Cancer, 13(1), 9.

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