Breast cancer is a heterogeneous disease with two most common types of breast cancer, ductal and lobular carcinoma, ductal being by far the most common. The development of targeted drug delivery shows the great promise to overcome the hurdles of conventional drug therapy approach in breast cancer treatment. Conjugation of nanocarriers with targeting ligands is a potential therapeutic approach to treat cancer diseases.
Fig.1 monoclonal antibodies and small-molecule inhibitors for breast cancer
Breast cancer targeted drugs obstruct the growth of cancer through interfering with the function of specific molecules that are responsible for cancer cell proliferation, survival, migration, invasion, metastasis, apoptosis, cell-cycle progression, angiogenesis and other vital cell cycle pathways. With the latest developments in molecular biology and immunotherapy, tailoring personalized therapies have been tailored to the specific pathophysiology of different types of breast cancers. Targeted therapy drugs which are generally available for breast cancer are listed below.
|Target||Types||Agent||Manufacturer||Start Marketing Date|
|mTOR||Small molecule||Certican Afinitor Zortress||Novartis||2009|
|EGFR, HER2||Small molecule||Tykerb||GSK||2007|
|EGFR, HER2, HER4||Small molecule||Nerlynx||2017|
|EGFR, HER2||Small molecule||airuini||Hengrui||2018|
In the field of cancer treatment, it was observed that the bacteria have the ability to deliver tumor-specific anticancer genes and the potential tumor-targeting antitumor capability. As a leader in oncolytic bacteria genome editing, Creative Biogene provides a "one-stop shop" tailored to your gene research needs. We have expertise in gene knockout, knock-in/replacement and site-directed mutagenesis. Creative Biogene is able to provide you the comprehensive oncolytic bacteria genome editing service, including traditional recombineering system, CRISPR/Cas 9 system and site-specific recombination system.
• non-toxic to the host
• selective for a specific type of tumor
• harmless to normal tissue
• manipulated easily
Creative Biogene is dedicated to providing Complete Solutions for oncolytic bacteria genome editing to help you every step of the way in your genome editing workflow. And we offer full-service for genetic modification which has been successfully achieved in microorganisms, such as E. coli, Salmonella, Streptomyces, Clostridium, Bacillus subtilis, Saccharomyces cerevisiae, filamentous fungi, and so on. Simply let us know how you want the genome to be edited. We will propose the best strategy for you.
1. Munagala, R., Aqil, F., & Gupta, R. C. (2011). Promising molecular targeted therapies in breast cancer. Indian journal of pharmacology, 43(3), 236–245.
2. Gomhor J. Alqaraghulia, Hasanain & Kashanian, Soheila & Rafipour, Ronak. (2019). A Review on Targeting Nanoparticles for Breast Cancer. Current pharmaceutical biotechnology. 20.
3. Masoud, V., & Pagès, G. (2017). Targeted therapies in breast cancer: New challenges to fight against resistance. World journal of clinical oncology, 8(2), 120–134.