As one of the global leaders in genetic engineering development, Creative Biogene offers complete customized genome editing services for nutraceuticals production.
Nutraceuticals are an important class of chemical compounds that exhibit great benefit on human health including antioxidant property, chronic disease prevention, anti-inflammation, anticancer and other physiological functions. For a long time, nutraceuticals were isolated and sourced from traditional extraction of plants, animals and marine fish oils. However, conversations about environment pollution and sustainability problems of natural resources during the traditional extraction process spur a new trend towards nutraceuticals production—that is microbial fermentation.1
Metabolic engineering of nutraceuticals producing strains acts as an attractive alternative to traditional extraction and chemical synthesis. This process uses low-cost lignocellulosic feedstocks to produce compounds of interest with long-term sustainability property. Genetic engineering of microorganisms that natively or adjectively produce these molecules has been well developed to achieve high-yield nutraceuticals production.
Creative Biogene focus on microbial genetic engineering technology development with an advanced platform that provides services for nutraceuticals producing strains engineering. Common strains like E.coli, Saccharomyces cerevisiae have already been explored to produce nutraceutical products in large scale industry manufacturing. Beneficial substances comprising of CoQ10, polyunsaturated fatty acids, polyphenols have been produced by these engineered strains for decades. Apart from standard organisms, uncommon strain such as Yarrowia lipolytica2 has been extensively studied for its ability to produce quantities of lipid, especially Omega-3.
Fig 1. Production of nutraceuticals
Based on years of experience and acquired knowledge, Creative Biogene offers a broad spectrum of genome engineering services using technologies such as CRISPR/Cas9, homologous recombination and site-specific recombination. If you have any requirements for nutraceuticals producing strain engineering, please don't hesitate to contact us and we are looking forward to corporating with your attractive projects.
1. Yuan, S., Alper, H.S (2019). 'Metabolic engineering of microbial cell factories for production of nutraceuticals.' Microb Cell Fact 18, 46.
2. Xie, D., Jackson, E. N., & Zhu, Q. (2015). 'Sustainable source of omega-3 eicosapentaenoic acid from metabolically engineered Yarrowia lipolytica: from fundamental research to commercial production.' Applied microbiology and biotechnology, 99(4), 1599–1610.