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Metabolic Pathway Synthesis and Library Assembly Services

Microbiosci is a leading company offering the best Metabolic Pathway Synthesis and Library Assembly Services. With extensive experience, our talented scientists have developed a novel and simple technology for flexible design of a bespoke metabolic pathway. They would research closely with you to offer help in Metabolic Pathway Synthesis.

As an emerging area of research, Synthetic biology can extensively be defined as the design and construction of novel artificial biological pathways, organisms or devices, or the redesign of existing natural biological systems. Metabolic engineering deals with the engineering (design, construction, and optimization) for the microbial synthesis of native as well as non-natural routes of product1. A prime example of using metabolic engineering to produce an active pharmaceutical ingredient is the semi-synthesis of the antimalarial drug artemisinin with S. cerevisiae engineered to produce artemisinic acid, the most complex part of the molecule2.

Metabolic Pathway Synthesis and Library Assembly Services

Figure 1. Schematic representation of the engineered artemisinic acid biosynthetic pathway in S. cerevisiae strain EPY224 expressing CYP71AV1 and CPR3

Microbial production of natural products has been enabled by transferring entire metabolic pathways or specific enzymes from rare or genetically intractable organisms to those that can be readily engineered2. Microbial production of unnatural products has been achieved by combining enzymes or pathways from different hosts into a single microorganism and by engineering enzymes to have new function2. Metabolic engineering will be the future of biotechnology and soon rival and potentially eclipse synthetic organic chemistry2.

Metabolic Pathway Synthesis and Library Assembly Services

Figure 2 Manufacturing Molecules Through Metabolic Engineering2

Advantages of metabolic pathway synthesis and Library Assembly Services

• One-stop, high-throughput solution
• Highly-customizable
• Faster & More economical
• Seamlessly assembled with advanced methods

As a leader in Metabolic Pathway Synthesis and Library Assembly Services, Microbiosci provides a "one-stop shop" tailored to your research needs. We have expertise in metabolic pathway synthesis service as well as customized metabolic pathway library assembly service. The flexibility allows easy customization to fit how you run projects.

References:
1. Stephanopoulos, G. (2012). Synthetic biology and metabolic engineering. Acs Synthetic Biology, 1(11), 514-525.
2. Keasling, J. D. (2010). Manufacturing molecules through metabolic engineering. Science, 330(6009), 1355-1358.
3. Ro, D. K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., & Ndungu, J. M., et al. (2006). Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature, 440(7086), 940-943.
4. Martin, V. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003). Engineering a mevalonate pathway in escherichia coli for production of terpenoids. Nature Biotechnology, 21(7), 796-802.
5. Ajikumar, P. K., Xiao, W. H., Tyo, K. E. J., Wang, Y., Simeon, F., & Leonard, E., et al. (2010). Isoprenoid pathway optimization for taxol precursor overproduction in escherichia coli. Science, 330(6000), 70.
6. Xue, Z., Sharpe, P. L., Hong, S. P., Yadav, N. S., Xie, D., & Short, D. R., et al. (2013). Production of omega-3 eicosapentaenoic acid by metabolic engineering of yarrowia lipolytica. Nature Biotechnology, 31(8), 734-40.
7. Kallio, P., Pásztor, A., Thiel, K., Akhtar, M. K., & Jones, P. R. (2014). An engineered pathway for the biosynthesis of renewable propane. Nature Communications, 5(1), 4731.
8. Xu, P., Li, L., Zhang, F., Stephanopoulos, G., & Koffas, M. (2014). Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proceedings of the National Academy of Sciences of the United States of America, 111(31), 11299.
9. Galanie, S., Thodey, K., Trenchard, I. J., Filsinger, I. M., & Smolke, C. D. (2015). Complete biosynthesis of opioids in yeast. Science, 349(6252), 1095-1100.

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