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Microbiome, refers to the collective genome of all the microorganisms, symbiotic and pathogenic inhabiting an environment. The gut microbiome is comprised of tremendous organisms that living in the human gut, including bacteria, archaea, viruses, and fungi, which play key contribute to host metabolism and are considered potential sources of novel therapeutics. Several diseases are now thought to be influenced by processes in the gut microbiome. Those include cancer, autoimmune disorders such as multiple sclerosis and autism spectrum disorder. The gut microbiome also strongly interacts with certain drugs, including some mental-health therapeutics, and influences their effects.
Microbiosci offers extensive microbiome analysis portfolio includes not only consultancy, study design, sampling solutions and sequencing, but also downstream bioinformatic and biostatistical analyses.
With next-generation sequencing (NGS) technology we have the tool to analyse the human gut microbiome. With this high-throughput technology we can perform complete metagenomics studies capable of surveying the genomes of entire communities, including those of unculturable organisms.
1. Fuhrman JA. 2009. Microbial community structure and its functional implications. Nature 459:193–199.doi:10.1038/nature08058.
2. Zhou J, He Z, Yang Y, Deng Y, Tringe SG, Alvarez-Cohen L. 2015. High-throughput metagenomic technologies for complex microbial community analysis: open and closed formats. mBio 6(1):e02288-14. doi:10.1128/mBio.02288-14.