As an experienced manufacturer of recombinant proteins, Microbiosci's goal is to deliver cost-effective and time-saving recombinant protein fermentation services.
At Microbiosci, we have proprietary microbial fermentation technology which facilitates us to provide customers comprehensive recombinant protein production services.
We develop cGMP or non-cGMP recombinant protein production for clinical trial and commercial uses. Our cGMP operation procedure and facilities for protein production are compliant with the current standards in food and drug manufacturing practice.
• Recombinant protein fermentation services
• Strain development
• Process scale up and scale down
• Protein purification and formulation
• Inclusion protein refolding and endotoxin removal
• cGMP or non-cGMP grade manufacturing
In general terms, the recombinant proteins for industrial use (IRPs) are usually produced by microorganisms while the pharmaceutical recombinant proteins (PRPs) are usually produced by mammalian cells and yeasts.
Microorganisms have been developed well to produce recombinant proteins since the 20th century. The representative microbes are bacteria, yeast, fungus and microalgae.
|Bacteria||Easy genetic manipulation, annotated genomes and metabolic pathways, high yield of recombinant proteins||E.coli, Bacillus, Corynebacterium glutamicum|
|Yeast||Post-translation modification, capability to produce human proteins, fast growth rate, low cost||Saccharomyces cerevisiae, Pichia pastoris|
|Fungus||promising producers of commercially interesting compounds||Aspergillus niger, Botrytis cinerea, Cyathus africanus, Mortierella minutissima|
|Microalgae||Heterotrophic production, utilization of a wide range of carbon and nitrogen sources||The green algae, the dinoflagellates, and the thraustochytrids|
Microbiosci handles a wide range of organisms for production of recombinant proteins for clinical and commercial uses. Our fermentation facility is fully equipped and complaint with the current good manufacturing practice and we are dedicated to provide you with useful solutions for large-scale protein manufacturing. For more details, including pricing, please inquire at email@example.com along with more information regarding your attractive project.
1. Barclay, W. , Apt, K. , & Dong, X. D. . (0). 'Commercial Production of Microalgae via Fermentation.' Handbook of Microalgal Culture. John Wiley & Sons, Ltd.
2. Carla C C R de Carvalho. (2016). 'Fungi in Fermentation and Biotransformation Systems.' Biology of Microfungi. Springer International Publishing.