Fermentation for Recombinant Proteins

As an experienced manufacturer of recombinant proteins, Creative Biogene's goal is to deliver cost-effective and time-saving recombinant protein fermentation services.

Recombinant Protein Production Services

At Creative Biogene, we have proprietary microbial fermentation technology which facilitates us to provide customers comprehensive recombinant protein production services.

We develop cGMP or non-cGMP recombinant protein production for clinical trial and commercial uses. Our cGMP operation procedure and facilities for protein production are compliant with the current standards in food and drug manufacturing practice.

Fermentation for Recombinant Proteins

• Recombinant protein fermentation services
• Strain development
• Process scale up and scale down
• Protein purification and formulation
• Inclusion protein refolding and endotoxin removal
• cGMP or non-cGMP grade manufacturing

Protein Expression Profiles of Different Hosts

In general terms, the recombinant proteins for industrial use (IRPs) are usually produced by microorganisms while the pharmaceutical recombinant proteins (PRPs) are usually produced by mammalian cells and yeasts.

Microorganisms have been developed well to produce recombinant proteins since the 20th century. The representative microbes are bacteria, yeast, fungus and microalgae.

HostsCharacteristicsPlatform strains
BacteriaEasy genetic manipulation, annotated genomes and metabolic pathways, high yield of recombinant proteinsE.coli, Bacillus, Corynebacterium glutamicum
YeastPost-translation modification, capability to produce human proteins, fast growth rate, low costSaccharomyces cerevisiae, Pichia pastoris
Funguspromising producers of commercially interesting compoundsAspergillus niger, Botrytis cinerea, Cyathus africanus, Mortierella minutissima
MicroalgaeHeterotrophic production, utilization of a wide range of carbon and nitrogen sourcesThe green algae, the dinoflagellates, and the thraustochytrids

Flow Chart of Fermentation Services at Creative Biogene

Fermentation for Recombinant Proteins

About Creative Biogene

Creative Biogene handles a wide range of organisms for production of recombinant proteins for clinical and commercial uses. Our fermentation facility is fully equipped and complaint with the current good manufacturing practice and we are dedicated to provide you with useful solutions for large-scale protein manufacturing. For more details, including pricing, please inquire at along with more information regarding your attractive project.

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1. Barclay, W. , Apt, K. , & Dong, X. D. . (0). 'Commercial Production of Microalgae via Fermentation.' Handbook of Microalgal Culture. John Wiley & Sons, Ltd.
2. Carla C C R de Carvalho. (2016). 'Fungi in Fermentation and Biotransformation Systems.' Biology of Microfungi. Springer International Publishing.

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Creative Biogene is fully engaged in developing unique technologies that provide global scientists with high quality products and satisfactory services to facilitate the investigation of microbial researches.


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Microbial Fermentation

• Microbial Fermentation Service

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